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Colon - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		413	429	432	431	410	427	372	413	3327
Crude rate		60.7	63.5	64.2	64.5	61.6	63.3	54.2	59.9	61.4 (59.4‑63.6)
Standardized rate	Italy 2001	46.0	47.6	47.4	46.2	43.6	46.3	38.6	43.5	44.9 (43.4‑46.5)
Standardized rate	Europe	30.8	31.6	31.6	30.3	28.7	31.0	25.1	29.1	29.8 (28.7‑30.9)
Standardized rate	World	20.4	21.1	20.8	20.1	19.0	20.7	16.4	19.3	19.7 (18.9‑20.6)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		195	171	194	187	190	196	204	153	1490
Crude rate		28.7	25.3	28.8	28.0	28.6	29.0	29.7	22.2	27.5 (26.1‑29.0)
Standardized rate	Italy 2001	20.8	18.2	20.0	19.1	19.2	20.3	20.4	15.4	19.2 (18.2‑20.2)
Standardized rate	Europe	12.4	11.2	12.0	11.5	12.0	12.7	12.5	9.5	11.7 (11.1‑12.4)
Standardized rate	World	7.7	7.1	7.5	7.2	7.7	8.2	8.0	6.1	7.4 (7.0‑7.9)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	45.2	38.2	42.2	41.3	44.0	43.8	52.8	35.4	42.8
Cito-histologically confirmed (%)	86.4	89.0	89.4	90.7	89.3	92.0	90.3	93.9	90.1
Death certificate only - DCO (%)	2.2	2.1	2.8	2.1	3.4	2.1	2.2	0.7	2.2

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	28.5	30.5	29.5	29.8	22.8	28.6
Mortality	11.7	11.8	10.5	10.4	9.9	10.6

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	1515	88.9	1482	91.4	2997	90.1
Citological	1	0.1	1	0.1	2	0.1
Clinical	148	8.7	100	6.2	248	7.5
DCO	39	2.3	34	2.1	73	2.2

Table 6: More frequent morphologies

Morphology	N	%
Adenocarcinoma, NOS	1133	76.4
Mucinous adenocarcinoma	150	10.1
Adenocarcinoma in tubulovillous adenoma	81	5.5
Adenocarcinoma, intestinal type (C16._)	20	1.3
Mucin-producing adenocarcinoma	14	0.9
Adenocarcinoma in villous adenoma	14	0.9

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	0.0	0.0
25-29	1.3	0.0
30-34	3.2	0.5
35-39	2.7	0.5
40-44	10.0	2.5
45-49	12.3	5.8
50-54	33.6	9.6
55-59	54.7	14.9
60-64	72.7	31.9
65-69	94.3	36.5
70-74	154.3	58.6
75-79	194.5	75.0
80-84	239.0	122.1
85+	245.2	192.6

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	12.4	30.8
2000	11.2	31.6
2001	12.0	31.6
2002	11.5	30.3
2003	12.0	28.7
2004	12.7	31.0
2005	12.5	25.1
2006	9.5	29.1

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	77.6	46.0	81.6	84.6	85.3	85.7
2-5	80.9	46.4	86.0	85.7	93.6	97.8
5-10	91.4	48.3	94.8	95.8	107.9	111.1
10-15	58.6	26.9	58.5	70.0	65.5	63.0
15-20	32.9	16.7	37.3	34.2	39.4	37.6
>20	37.5	18.7	40.0	40.6	43.5	44.5

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	61.1 (58.5‑63.8)
North West	60.4 (59.0‑61.7)
North Est	61.2 (60.1‑62.4)
Centre	62.1 (60.1‑63.9)
South	56.1 (53.8‑58.3)
Italy	60.5 (59.7‑61.2)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	83.70	76.30	70.80	70.80	67.20
45-59	100.00	87.90	79.60	75.70	72.80	70.60
60-74	100.00	83.50	75.80	71.80	67.00	64.80
75+	100.00	70.00	62.50	58.40	54.70	54.40

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	76.3	76.5	76.9	79.9
2	67.9	68.5	69.5	72.7
3	63.9	63.2	65.9	69.2
4	59.8	58	61.5	66.6
5	58.4	56.6	59.7	66

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	59.5	58.9	58.7	53.1	58.3
Mortality	22.5	26.3	28.2	25.7	28.3

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	76.9	81.5
2	69.2	74.7
3	65.8	71.6
4	60.5	65.9
5	59.8	61.8