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Liver - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		215	194	209	203	200	207	215	227	1670
Crude rate		36.0	32.7	35.4	34.7	34.4	34.7	35.1	36.7	35.0 (33.3‑36.7)
Standardized rate	Italy 2001	36.4	32.5	34.5	33.8	32.9	33.7	34.4	36.1	34.3 (32.6‑36.0)
Standardized rate	Europe	24.6	22.1	23.8	22.8	22.1	22.8	24.1	25.0	23.4 (22.3‑24.6)
Standardized rate	World	16.8	15.1	16.1	15.3	14.7	15.4	16.9	17.1	15.9 (15.1‑16.8)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		174	158	177	171	155	181	147	181	1344
Crude rate		29.2	26.7	30.0	29.2	26.7	30.3	24.0	29.3	28.2 (26.7‑29.7)
Standardized rate	Italy 2001	30.1	26.9	29.8	29.0	25.3	29.8	24.0	29.2	28.0 (26.5‑29.5)
Standardized rate	Europe	19.5	17.2	19.3	19.1	16.3	19.7	14.4	18.6	18.0 (17.0‑19.0)
Standardized rate	World	12.8	11.2	13.0	12.6	10.8	13.2	9.0	12.2	11.8 (11.1‑12.5)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	82.7	82.8	86.4	85.8	76.9	88.4	69.8	80.9	81.6
Cito-histologically confirmed (%)	46.5	51.0	56.5	52.7	51.0	47.3	56.3	44.9	50.7
Death certificate only - DCO (%)	2.3	1.0	1.0	2.0	4.0	6.8	2.3	0.9	2.5

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	23.5	19.2	20.9	13.1	24.9	19.6
Mortality	17.2	14.9	15.2	11.4	17.8	14.9

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	353	43.0	353	41.6	706	42.3
Citological	71	8.7	70	8.2	141	8.4
Clinical	384	46.8	390	45.9	774	46.4
DCO	13	1.6	29	3.4	42	2.5

Table 6: More frequent morphologies

Morphology	N	%
Hepatocellular carcinoma, NOS (C22.0)	297	70.2
Hepatocellular carcinoma, fibrolamellar (C22.0)	40	9.5
Cholangiocarcinoma (C22.1, C24.0)	22	5.2
Adenocarcinoma, NOS	21	5.0
Hepatocellular carcinoma, clear cell type (C22.0)	13	3.1
Carcinoma, NOS	9	2.1

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	4.0	0.0
1-4	1.1	0.0
5-9	1.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	0.9	0.0
25-29	0.6	0.0
30-34	0.9	0.4
35-39	1.7	0.9
40-44	7.0	2.0
45-49	17.1	6.1
50-54	24.5	15.6
55-59	47.1	19.5
60-64	64.5	51.1
65-69	88.0	70.1
70-74	135.9	103.7
75-79	156.1	139.0
80-84	141.7	167.4
85+	143.6	137.7

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	19.5	24.6
2000	17.2	22.1
2001	19.3	23.8
2002	19.1	22.8
2003	16.3	22.1
2004	19.7	22.8
2005	14.4	24.1
2006	18.6	25.0

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	25.9	25.9	20.4	27.4	27.0	36.0
2-5	16.3	16.0	10.2	16.2	20.8	26.3
5-10	7.6	7.9	5.3	6.5	10.5	13.6
10-15	2.4	2.1	1.7	2.7	2.7	3.6
15-20	0.4	0.4	0.6	0.3	0.4	0.7
>20	0.2	0.1	0.1	0.2	0.4	0.2

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	20.6 (17.5‑23.6)
North West	17.1 (15.7‑18.6)
North Est	14.6 (13.4‑15.8)
Centre	13.8 (11.5‑16.2)
South	15.0 (13.1‑17.0)
Italy	15.4 (14.6‑16.2)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	64.00	49.80	44.00	41.10	37.70
45-59	100.00	56.50	41.60	36.10	31.40	27.40
60-74	100.00	58.90	43.50	34.10	26.80	21.70
75+	100.00	46.00	31.00	23.60	16.70	13.90

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	50.1	57.4	53	58.5
2	37.7	41.4	37.7	42
3	27.3	33	32.2	33.9
4	20.1	24.7	25.9	29.3
5	13.9	20.4	22.5	26.4

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	24.3	28.1	32	40.2	43.2
Mortality	20.9	24.2	26.5	27.8	31.6

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	56.7	61.3
2	40.4	49.4
3	33.0	36.3
4	28.8	29.3
5	24.1	25.6