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Leukaemias - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		109	131	119	132	130	122	110	120	973
Crude rate		18.3	22.1	20.2	22.6	22.4	20.4	17.9	19.4	20.4 (19.1‑21.7)
Standardized rate	Italy 2001	19.5	22.8	20.4	23.3	22.1	20.2	18.1	19.2	20.6 (19.3‑22.0)
Standardized rate	Europe	14.5	17.4	15.3	18.4	15.8	15.2	13.4	15.3	15.6 (14.6‑16.7)
Standardized rate	World	11.3	14.0	12.0	15.2	11.6	11.8	10.1	13.0	12.4 (11.4‑13.4)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		80	71	79	87	81	64	76	69	607
Crude rate		13.4	12.0	13.4	14.9	13.9	10.7	12.4	11.2	12.7 (11.7‑13.8)
Standardized rate	Italy 2001	14.7	12.9	14.1	16.0	14.3	10.6	13.8	11.6	13.4 (12.4‑14.6)
Standardized rate	Europe	9.5	8.4	9.1	9.8	9.7	7.1	8.7	7.3	8.7 (7.9‑9.4)
Standardized rate	World	6.8	5.8	6.3	6.3	7.0	5.1	5.9	5.0	6.0 (5.4‑6.7)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	75.4	56.6	69.1	68.7	64.7	52.5	76.2	60.4	65.0
Cito-histologically confirmed (%)	89.9	96.2	95.8	97.7	96.2	97.5	96.4	98.3	96.1
Death certificate only - DCO (%)	3.7	1.5	1.7	0.8	0.8	2.5	1.8	0.8	1.6

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	14.9	12.7	11.9	10.7	12.4	11.8
Mortality	8.2	7.3	7.0	7.9	7.5	7.3

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	467	95.1	468	97.1	935	96.1
Citological	0	0.0	0	0.0	0	0.0
Clinical	15	3.1	7	1.5	22	2.3
DCO	9	1.8	7	1.5	16	1.6

Table 6: More frequent morphologies

Morphology	N	%
B-cell chronic leukaemia small lymphocytic lymphoma (see also M96703)	176	37.6
Acute myeloid leukaemia, NOS (FAB or WHO type not specified) (see also M99303)	124	26.5
Chronic myeloid leukaemia, NOS	39	8.3
Hairy cell leukaemia (C42.1)	33	7.1
Precursor cell lymphoblastic leukaemia, NOS (see also M97273)	25	5.3
Acute myeloid leukaemia with multilineage dysplasia	14	3.0

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	7.8	1.1
5-9	10.2	3.1
10-14	5.4	2.1
15-19	2.2	1.1
20-24	0.9	1.9
25-29	3.1	1.2
30-34	3.1	0.9
35-39	5.2	0.9
40-44	6.5	2.5
45-49	11.6	3.1
50-54	20.4	7.5
55-59	20.1	8.2
60-64	36.4	17.9
65-69	43.0	25.8
70-74	55.0	31.4
75-79	70.6	51.3
80-84	76.8	70.0
85+	105.5	131.9

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	9.5	14.5
2000	8.4	17.4
2001	9.1	15.3
2002	9.8	18.4
2003	9.7	15.8
2004	7.1	15.2
2005	8.7	13.4
2006	7.3	15.3

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	20.1	20.5	16.8	17.9	25.7	24.5
2-5	22.0	20.3	19.8	22.0	24.7	31.0
5-10	25.0	25.4	23.2	23.6	29.2	30.0
10-15	14.7	13.2	13.1	15.3	14.5	16.3
15-20	7.8	8.2	7.4	6.7	9.7	9.5
>20	8.0	8.8	7.4	7.6	8.6	9.4

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	50.6 (45.9‑55.3)
North West	48.6 (46.1‑51.0)
North Est	45.1 (43.0‑47.1)
Centre	41.5 (38.1‑44.9)
South	44.8 (41.5‑48.1)
Italy	45.5 (44.2‑46.8)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	77.70	64.50	59.60	59.60	59.60
45-59	100.00	85.10	78.20	74.30	69.00	66.90
60-74	100.00	73.90	64.10	60.00	57.50	54.10
75+	100.00	56.10	46.40	38.60	36.40	32.80

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	76.1	74.8	67.4	69.2
2	66.7	65.7	56.1	61.8
3	58.9	62.1	51.2	57.4
4	56.3	58.1	50.2	54.2
5	51.2	56.8	46.5	53.1

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	20.5	17.9	16.6	20	19.6
Mortality	12.4	8.9	12	13.1	11

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	68.6	63.9
2	58.8	54.1
3	55.1	50.0
4	52.9	48.8
5	49.0	43.0