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Liver - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		97	96	115	91	111	108	111	101	830
Crude rate		14.3	14.2	17.1	13.6	16.7	16.0	16.2	14.6	15.3 (14.3‑16.4)
Standardized rate	Italy 2001	10.8	10.2	12.3	9.7	11.6	11.2	11.1	10.3	10.9 (10.2‑11.7)
Standardized rate	Europe	6.8	6.3	7.4	6.1	7.0	6.8	6.7	6.3	6.7 (6.2‑7.2)
Standardized rate	World	4.7	4.0	4.7	4.0	4.4	4.3	4.3	4.2	4.3 (4.0‑4.7)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		116	101	105	100	100	85	92	90	789
Crude rate		17.1	14.9	15.6	15.0	15.0	12.6	13.4	13.0	14.6 (13.6‑15.6)
Standardized rate	Italy 2001	12.4	10.8	11.0	10.4	10.4	8.6	8.8	8.8	10.2 (9.5‑10.9)
Standardized rate	Europe	7.1	6.6	6.3	6.2	6.3	5.0	5.0	5.3	6.0 (5.5‑6.5)
Standardized rate	World	4.4	4.1	3.9	4.0	4.0	3.1	3.1	3.2	3.7 (3.4‑4.1)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	114.8	105.9	89.4	107.2	89.7	76.8	79.3	85.4	93.6
Cito-histologically confirmed (%)	36.1	36.5	38.3	44.0	34.2	38.9	36.0	39.6	37.8
Death certificate only - DCO (%)	5.2	7.3	6.1	11.0	8.1	4.6	7.2	8.9	7.2

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	6.7	5.8	6.3	4.7	9.1	6.3
Mortality	5.4	5.0	4.8	4.7	7.4	5.2

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	131	32.8	141	32.7	272	32.8
Citological	23	5.8	19	4.4	42	5.1
Clinical	216	54.1	238	55.2	454	54.7
DCO	29	7.3	31	7.2	60	7.2

Table 6: More frequent morphologies

Morphology	N	%
Hepatocellular carcinoma, NOS (C22.0)	96	60.0
Cholangiocarcinoma (C22.1, C24.0)	20	12.5
Hepatocellular carcinoma, fibrolamellar (C22.0)	15	9.4
Adenocarcinoma, NOS	12	7.5
Carcinoma, NOS	6	3.8
Hepatocellular carcinoma, clear cell type (C22.0)	3	1.9

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	4.3	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	0.0	0.0
25-29	0.0	0.0
30-34	0.0	0.0
35-39	0.5	0.0
40-44	1.5	0.0
45-49	2.3	1.2
50-54	2.4	3.0
55-59	5.3	5.8
60-64	12.0	11.5
65-69	25.5	15.6
70-74	49.0	35.9
75-79	75.0	58.4
80-84	73.6	75.3
85+	51.6	58.6

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	7.1	6.8
2000	6.6	6.3
2001	6.3	7.4
2002	6.2	6.1
2003	6.3	7.0
2004	5.0	6.8
2005	5.0	6.7
2006	5.3	6.3

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	10.5	10.7	6.8	10.6	12.4	15.4
2-5	5.6	6.0	4.3	5.3	6.8	9.2
5-10	2.6	3.7	2.9	1.3	4.2	5.2
10-15	1.8	1.3	1.0	2.4	1.4	1.8
15-20	0.5	0.8	0.3	0.3	0.6	0.5
>20	0.8	1.1	0.6	0.7	0.7	1.1

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	19.7 (15.7‑23.7)
North West	17.6 (15.0‑20.4)
North Est	15.3 (12.8‑18.0)
Centre	17.4 (13.0‑22.4)
South	13.6 (10.8‑16.7)
Italy	16.0 (14.5‑17.5)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	46.30	34.20	29.40	24.60	24.60
45-59	100.00	55.30	45.10	33.60	25.60	19.50
60-74	100.00	40.40	28.80	20.40	15.20	11.80

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	45.8	44.8	50	46.5
2	32	30.8	41.4	37.8
3	21.5	23.5	32.4	27
4	17.5	15.2	23.6	23.1
5	13.9	11	19.7	17.7

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	13.2	14.3	15.1	16.7	17.2
Mortality	12	11	14.7	13	14.5

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	45.3	51.7
2	35.2	40.6
3	25.8	32.2
4	19.4	25.2
5	15.0	16.2