Leukaemias - GentsRates per 100,000 inhabitants
Table 1: Incidence: frequencies, crude and standardized rates per year
Incidence | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 109 | 131 | 119 | 132 | 130 | 122 | 110 | 120 | 973 |
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Crude rate | 18.3 | 22.1 | 20.2 | 22.6 | 22.4 | 20.4 | 17.9 | 19.4 | 20.4 (19.1‑21.7) |
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Standardized rate | Italy 2001 | 19.5 | 22.8 | 20.4 | 23.3 | 22.1 | 20.2 | 18.1 | 19.2 | 20.6 (19.3‑22.0) |
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Standardized rate | Europe | 14.5 | 17.4 | 15.3 | 18.4 | 15.8 | 15.2 | 13.4 | 15.3 | 15.6 (14.6‑16.7) |
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Standardized rate | World | 11.3 | 14.0 | 12.0 | 15.2 | 11.6 | 11.8 | 10.1 | 13.0 | 12.4 (11.4‑13.4) |
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Table 2: Mortality: frequencies, crude and standardized rates per year
Mortality | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 80 | 71 | 79 | 87 | 81 | 64 | 76 | 69 | 607 |
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Crude rate | 13.4 | 12.0 | 13.4 | 14.9 | 13.9 | 10.7 | 12.4 | 11.2 | 12.7 (11.7‑13.8) |
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Standardized rate | Italy 2001 | 14.7 | 12.9 | 14.1 | 16.0 | 14.3 | 10.6 | 13.8 | 11.6 | 13.4 (12.4‑14.6) |
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Standardized rate | Europe | 9.5 | 8.4 | 9.1 | 9.8 | 9.7 | 7.1 | 8.7 | 7.3 | 8.7 (7.9‑9.4) |
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Standardized rate | World | 6.8 | 5.8 | 6.3 | 6.3 | 7.0 | 5.1 | 5.9 | 5.0 | 6.0 (5.4‑6.7) |
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Table 3: Register quality indicators per year
Indicator | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Mortality/Incidence ratio (%) | 75.4 | 56.6 | 69.1 | 68.7 | 64.7 | 52.5 | 76.2 | 60.4 | 65.0 |
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Cito-histologically confirmed (%) | 89.9 | 96.2 | 95.8 | 97.7 | 96.2 | 97.5 | 96.4 | 98.3 | 96.1 |
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Death certificate only - DCO (%) | 3.7 | 1.5 | 1.7 | 0.8 | 0.8 | 2.5 | 1.8 | 0.8 | 1.6 |
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Table 4: Comparison of Italian Registries mean prevalence by macro-areas
_ | Milan | North West | North East | Centre | South | Italy |
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Incidence | 14.9 | 12.7 | 11.9 | 10.7 | 12.4 | 11.8 |
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Mortality | 8.2 | 7.3 | 7.0 | 7.9 | 7.5 | 7.3 |
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Table 5: Basis of diagnosis per period
_ | 1999‑2002 | % | 2003‑2006 | % | 1999‑2006 | % |
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Histological | 467 | 95.1 | 468 | 97.1 | 935 | 96.1 |
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Citological | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
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Clinical | 15 | 3.1 | 7 | 1.5 | 22 | 2.3 |
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DCO | 9 | 1.8 | 7 | 1.5 | 16 | 1.6 |
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Table 6: More frequent morphologies
Morphology | N | % |
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B-cell chronic leukaemia small lymphocytic lymphoma (see also M96703) | 176 | 37.6 |
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Acute myeloid leukaemia, NOS (FAB or WHO type not specified) (see also M99303) | 124 | 26.5 |
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Chronic myeloid leukaemia, NOS | 39 | 8.3 |
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Hairy cell leukaemia (C42.1) | 33 | 7.1 |
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Precursor cell lymphoblastic leukaemia, NOS (see also M97273) | 25 | 5.3 |
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Acute myeloid leukaemia with multilineage dysplasia | 14 | 3.0 |
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Table 7: Age distribution of rates
Age groups | Incidence | Mortality |
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0 | 0.0 | 0.0 |
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1-4 | 7.8 | 1.1 |
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5-9 | 10.2 | 3.1 |
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10-14 | 5.4 | 2.1 |
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15-19 | 2.2 | 1.1 |
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20-24 | 0.9 | 1.9 |
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25-29 | 3.1 | 1.2 |
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30-34 | 3.1 | 0.9 |
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35-39 | 5.2 | 0.9 |
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40-44 | 6.5 | 2.5 |
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45-49 | 11.6 | 3.1 |
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50-54 | 20.4 | 7.5 |
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55-59 | 20.1 | 8.2 |
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60-64 | 36.4 | 17.9 |
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65-69 | 43.0 | 25.8 |
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70-74 | 55.0 | 31.4 |
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75-79 | 70.6 | 51.3 |
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80-84 | 76.8 | 70.0 |
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85+ | 105.5 | 131.9 |
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Table 8: Temporal trends of rates
Year | Mortality | Incidence |
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1999 | 9.5 | 14.5 |
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2000 | 8.4 | 17.4 |
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2001 | 9.1 | 15.3 |
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2002 | 9.8 | 18.4 |
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2003 | 9.7 | 15.8 |
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2004 | 7.1 | 15.2 |
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2005 | 8.7 | 13.4 |
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2006 | 7.3 | 15.3 |
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Table 10: Comparison of Italian Registries mean prevalence by macro-areas
Years since diagnosis | Italy | South | Centre | North East | North West | Milan |
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0-2 | 20.1 | 20.5 | 16.8 | 17.9 | 25.7 | 24.5 |
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2-5 | 22.0 | 20.3 | 19.8 | 22.0 | 24.7 | 31.0 |
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5-10 | 25.0 | 25.4 | 23.2 | 23.6 | 29.2 | 30.0 |
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10-15 | 14.7 | 13.2 | 13.1 | 15.3 | 14.5 | 16.3 |
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15-20 | 7.8 | 8.2 | 7.4 | 6.7 | 9.7 | 9.5 |
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>20 | 8.0 | 8.8 | 7.4 | 7.6 | 8.6 | 9.4 |
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Table 11: 5 years relative survival by macro-areas
Area | Relative survival (95% CI) |
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Milan | 50.6 (45.9‑55.3) |
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North West | 48.6 (46.1‑51.0) |
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North Est | 45.1 (43.0‑47.1) |
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Centre | 41.5 (38.1‑44.9) |
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South | 44.8 (41.5‑48.1) |
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Italy | 45.5 (44.2‑46.8) |
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Table 12: Relative survival by age since diagnosis
Age class | 0 | 1 | 2 | 3 | 4 | 5 |
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15-44 | 100.00 | 77.70 | 64.50 | 59.60 | 59.60 | 59.60 |
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45-59 | 100.00 | 85.10 | 78.20 | 74.30 | 69.00 | 66.90 |
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60-74 | 100.00 | 73.90 | 64.10 | 60.00 | 57.50 | 54.10 |
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75+ | 100.00 | 56.10 | 46.40 | 38.60 | 36.40 | 32.80 |
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Table 13: 5 years relative survival by biennium of incidence
Years since diagnosis | 1999‑2000 | 2001‑2002 | 2003‑2004 | 2005‑2006 |
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1 | 76.1 | 74.8 | 67.4 | 69.2 |
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2 | 66.7 | 65.7 | 56.1 | 61.8 |
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3 | 58.9 | 62.1 | 51.2 | 57.4 |
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4 | 56.3 | 58.1 | 50.2 | 54.2 |
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5 | 51.2 | 56.8 | 46.5 | 53.1 |
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Table 14: Rates distribution by deprivation index
‑ | 1 | 2 | 3 | 4 | 5 |
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Incidence | 20.5 | 17.9 | 16.6 | 20 | 19.6 |
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Mortality | 12.4 | 8.9 | 12 | 13.1 | 11 |
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Table 15: Relative survival by deprivation index
Years since diagnosis | Most deprived | Most affluent |
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0 | 100.0 | 100.0 |
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1 | 68.6 | 63.9 |
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2 | 58.8 | 54.1 |
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3 | 55.1 | 50.0 |
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4 | 52.9 | 48.8 |
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5 | 49.0 | 43.0 |
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