Myeloid leukaemias - GentsRates per 100,000 inhabitants
Table 1: Incidence: frequencies, crude and standardized rates per year
Incidence | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 45 | 45 | 53 | 58 | 47 | 62 | 52 | 55 | 417 |
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Crude rate | 7.5 | 7.6 | 9.0 | 9.9 | 8.1 | 10.4 | 8.5 | 8.9 | 8.7 (7.9‑9.6) |
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Standardized rate | Italy 2001 | 8.2 | 7.9 | 9.0 | 10.3 | 8.0 | 10.3 | 8.3 | 9.2 | 8.9 (8.0‑9.8) |
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Standardized rate | Europe | 5.8 | 5.8 | 6.3 | 7.9 | 5.4 | 7.3 | 6.2 | 6.8 | 6.4 (5.8‑7.1) |
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Standardized rate | World | 4.3 | 4.4 | 4.4 | 6.5 | 3.6 | 5.5 | 4.8 | 5.1 | 4.8 (4.3‑5.4) |
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Table 2: Mortality: frequencies, crude and standardized rates per year
Mortality | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 46 | 37 | 37 | 33 | 43 | 36 | 40 | 37 | 309 |
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Crude rate | 7.7 | 6.2 | 6.3 | 5.6 | 7.4 | 6.0 | 6.5 | 6.0 | 6.5 (5.8‑7.2) |
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Standardized rate | Italy 2001 | 8.1 | 6.7 | 6.3 | 6.0 | 7.5 | 5.9 | 6.9 | 6.2 | 6.7 (5.9‑7.5) |
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Standardized rate | Europe | 5.4 | 4.6 | 4.2 | 3.6 | 4.9 | 3.9 | 4.6 | 4.1 | 4.4 (3.9‑5.0) |
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Standardized rate | World | 4.0 | 3.4 | 2.8 | 2.2 | 3.3 | 2.6 | 3.2 | 2.8 | 3.0 (2.7‑3.5) |
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Table 3: Register quality indicators per year
Indicator | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Mortality/Incidence ratio (%) | 98.8 | 84.8 | 70.0 | 58.3 | 93.8 | 57.3 | 83.1 | 67.4 | 75.3 |
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Cito-histologically confirmed (%) | 93.3 | 97.8 | 92.5 | 98.3 | 95.7 | 100.0 | 98.1 | 98.2 | 96.9 |
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Death certificate only - DCO (%) | 2.2 | 2.2 | 1.9 | 0.0 | 0.0 | 0.0 | 1.9 | 1.8 | 1.2 |
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Table 4: Comparison of Italian Registries mean prevalence by macro-areas
_ | Milan | North West | North East | Centre | South | Italy |
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Incidence | 6.4 | 5.4 | 5.1 | 4.9 | 5.0 | 5.0 |
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Mortality | 4.4 | 3.1 | 3.2 | 4.0 | 2.8 | 3.2 |
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Table 5: Basis of diagnosis per period
_ | 1999‑2002 | % | 2003‑2006 | % | 1999‑2006 | % |
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Histological | 192 | 95.5 | 212 | 98.2 | 404 | 96.9 |
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Citological | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
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Clinical | 6 | 3.0 | 2 | 0.9 | 8 | 1.9 |
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DCO | 3 | 1.5 | 2 | 0.9 | 5 | 1.2 |
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Table 6: More frequent morphologies
Morphology | N | % |
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Acute myeloid leukaemia, NOS (FAB or WHO type not specified) (see also M99303) | 124 | 58.5 |
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Chronic myeloid leukaemia, NOS | 39 | 18.4 |
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Acute myeloid leukaemia with multilineage dysplasia | 14 | 6.6 |
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Chronic myelogenous leukaemia, BCRABL positive | 11 | 5.2 |
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Chronic myelomonocytic leukaemia, NOS | 10 | 4.7 |
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Acute myelomonocytic leukaemia | 6 | 2.8 |
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Table 7: Age distribution of rates
Age groups | Incidence | Mortality |
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0 | 0.0 | 0.0 |
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1-4 | 0.0 | 0.0 |
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5-9 | 3.1 | 1.0 |
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10-14 | 1.1 | 1.1 |
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15-19 | 2.2 | 0.0 |
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20-24 | 0.0 | 0.0 |
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25-29 | 2.5 | 0.6 |
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30-34 | 0.9 | 0.0 |
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35-39 | 3.9 | 0.4 |
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40-44 | 2.5 | 1.0 |
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45-49 | 4.3 | 2.4 |
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50-54 | 7.5 | 4.1 |
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55-59 | 10.0 | 6.3 |
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60-64 | 17.2 | 10.2 |
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65-69 | 16.5 | 16.5 |
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70-74 | 26.7 | 22.0 |
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75-79 | 34.2 | 24.6 |
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80-84 | 34.2 | 29.0 |
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85+ | 52.7 | 61.5 |
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Table 8: Temporal trends of rates
Year | Mortality | Incidence |
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1999 | 5.4 | 5.8 |
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2000 | 4.6 | 5.8 |
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2001 | 4.2 | 6.3 |
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2002 | 3.6 | 7.9 |
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2003 | 4.9 | 5.4 |
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2004 | 3.9 | 7.3 |
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2005 | 4.6 | 6.2 |
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2006 | 4.1 | 6.8 |
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Table 10: Comparison of Italian Registries mean prevalence by macro-areas
Years since diagnosis | Italy | South | Centre | North East | North West | Milan |
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0-2 | 6.7 | 6.6 | 5.9 | 5.3 | 9.7 | 9.3 |
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2-5 | 4.7 | 5.1 | 5.5 | 4.3 | 4.8 | 6.9 |
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5-10 | 5.4 | 6.4 | 6.3 | 4.6 | 6.0 | 6.0 |
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10-15 | 3.2 | 2.7 | 3.3 | 3.1 | 2.7 | 3.5 |
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15-20 | 1.2 | 1.2 | 1.3 | 0.9 | 1.7 | 1.5 |
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>20 | 0.5 | 0.5 | 0.5 | 0.3 | 0.7 | 0.7 |
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Table 11: 5 years relative survival by macro-areas
Area | Relative survival (95% CI) |
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Milan | 22.4 (16.9‑28.0) |
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North West | 48.6 (46.1‑51.0) |
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North Est | 45.1 (43.0‑47.1) |
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Centre | 41.5 (38.1‑44.9) |
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South | 44.8 (41.5‑48.1) |
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Italy | 45.5 (44.2‑46.8) |
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Table 12: Relative survival by age since diagnosis
Age class | 0 | 1 | 2 | 3 | 4 | 5 |
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15-44 | 100.00 | 77.60 | 69.40 | 67.30 | 67.30 | 67.30 |
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45-59 | 100.00 | 70.00 | 58.10 | 52.30 | 46.40 | 44.90 |
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60-74 | 100.00 | 47.70 | 28.00 | 22.10 | 20.20 | 17.60 |
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75+ | 100.00 | 36.30 | 22.00 | 15.80 | 12.90 | 10.70 |
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Table 13: 5 years relative survival by biennium of incidence
Years since diagnosis | 1999‑2000 | 2001‑2002 | 2003‑2004 | 2005‑2006 |
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1 | 59.2 | 59.5 | 36.4 | 55.4 |
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2 | 40.7 | 43.3 | 23.8 | 43.6 |
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3 | 30.6 | 39.1 | 18.8 | 38.4 |
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4 | 26.2 | 36.8 | 16.8 | 36.8 |
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5 | 21 | 35 | 14.7 | 36.8 |
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Table 14: Rates distribution by deprivation index
‑ | 1 | 2 | 3 | 4 | 5 |
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Incidence | 9.2 | 6.7 | 8.3 | 9.3 | 8.9 |
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Mortality | 6.7 | 4.4 | 7.3 | 7.2 | 5.1 |
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Table 15: Relative survival by deprivation index
Years since diagnosis | Most deprived | Most affluent |
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0 | 100.0 | 100.0 |
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1 | 53.6 | 36.2 |
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2 | 42.5 | 20.9 |
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3 | 40.3 | 14.3 |
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4 | 38.4 | 14.3 |
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5 | 36.5 | 12.3 |
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