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Non Hodgkin - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		174	158	157	212	175	167	156	179	1378
Crude rate		29.2	26.7	26.6	36.2	30.1	28.0	25.4	28.9	28.9 (27.4‑30.4)
Standardized rate	Italy 2001	30.1	27.7	26.9	35.4	28.7	27.0	25.0	28.5	28.5 (27.0‑30.1)
Standardized rate	Europe	21.5	19.6	20.3	26.3	22.1	20.3	19.1	21.1	21.2 (20.0‑22.4)
Standardized rate	World	15.3	14.3	15.7	19.4	16.6	15.0	14.8	16.0	15.8 (14.8‑16.8)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		72	70	70	66	76	88	51	78	571
Crude rate		12.1	11.8	11.9	11.3	13.1	14.7	8.3	12.6	12.0 (11.0‑13.0)
Standardized rate	Italy 2001	12.6	12.7	12.3	11.5	12.9	14.8	8.2	12.9	12.2 (11.2‑13.3)
Standardized rate	Europe	8.5	7.8	7.9	7.5	8.6	9.6	5.3	7.8	7.9 (7.2‑8.6)
Standardized rate	World	5.8	4.9	5.4	5.0	6.1	6.5	3.4	5.0	5.3 (4.8‑5.8)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	41.9	45.8	45.7	32.5	44.9	54.8	32.8	45.3	42.8
Cito-histologically confirmed (%)	94.8	96.2	97.5	98.1	98.9	95.8	99.4	95.5	97.0
Death certificate only - DCO (%)	1.2	0.6	0.6	0.5	0.0	1.2	0.6	0.0	0.6

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	20.6	17.7	18.8	16.7	13.8	17.4
Mortality	7.8	6.2	6.3	5.5	5.4	6.0

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	678	96.7	659	97.3	1337	97.0
Citological	0	0.0	0	0.0	0	0.0
Clinical	18	2.6	14	2.1	32	2.3
DCO	5	0.7	3	0.4	8	0.6

Table 6: More frequent morphologies

Morphology	N	%
Malignant lymphoma, large B-cell, diffuse, NOS	233	35.2
Malignant lymphoma, non-Hodgkin's, NOS	120	18.2
Follicular lymphoma, NOS (see also M96753)	56	8.5
Marginal zone B-cell lymphoma, NOS	51	7.7
Malignant lymphoma, lymphoplasmacytic (see also M97613)	31	4.7
Mycosis fungoides (C44._)	30	4.5

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	3.3	0.0
5-9	2.0	1.0
10-14	3.2	0.0
15-19	6.7	1.1
20-24	7.4	0.9
25-29	4.3	1.2
30-34	5.4	0.4
35-39	12.1	1.7
40-44	17.5	4.5
45-49	23.8	3.7
50-54	19.7	2.0
55-59	40.2	12.6
60-64	47.2	14.0
65-69	64.2	27.8
70-74	64.4	39.3
75-79	95.2	64.2
80-84	114.4	68.3
85+	93.8	90.8

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	8.5	21.5
2000	7.8	19.6
2001	7.9	20.3
2002	7.5	26.3
2003	8.6	22.1
2004	9.6	20.3
2005	5.3	19.1
2006	7.8	21.1

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	36.9	25.9	37.0	37.3	44.0	40.6
2-5	38.7	26.3	32.1	42.7	45.0	49.5
5-10	45.3	31.5	42.5	46.8	53.0	52.8
10-15	25.7	17.3	21.1	29.5	30.1	30.7
15-20	14.3	10.8	12.1	15.9	15.6	18.1
>20	19.9	13.7	18.1	21.5	22.9	24.0

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	58.3 (55.0‑61.7)
North West	58.1 (56.0‑60.2)
North Est	61.3 (59.5‑63.1)
Centre	57.5 (54.2‑60.6)
South	53.0 (49.4‑56.4)
Italy	58.8 (57.6‑60.0)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	73.10	64.60	61.40	59.20	57.80
45-59	100.00	78.10	76.30	76.30	75.30	74.70
60-74	100.00	82.70	78.20	74.00	72.00	72.00
75+	100.00	61.40	54.30	47.60	42.00	39.50

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	72	73.4	74.3	72.7
2	66.2	65.8	69.2	67.2
3	64.9	62	63.7	64.5
4	62.2	59.6	59.5	63.2
5	60.1	57.2	59	61

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	22.6	23.7	28.6	22	27.4
Mortality	7.8	11.2	14.3	12.3	12.6

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	75.1	74.1
2	69.7	68.1
3	66.0	63.8
4	63.4	60.6
5	62.3	59.0