Skin melanoma - GentsRates per 100,000 inhabitants
Table 1: Incidence: frequencies, crude and standardized rates per year
Incidence | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 94 | 107 | 135 | 136 | 97 | 130 | 118 | 100 | 917 |
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Crude rate | 15.8 | 18.1 | 22.9 | 23.3 | 16.7 | 21.8 | 19.2 | 16.2 | 19.2 (18.0‑20.5) |
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Standardized rate | Italy 2001 | 15.5 | 17.3 | 22.4 | 22.4 | 15.7 | 20.6 | 18.4 | 16.1 | 18.5 (17.3‑19.8) |
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Standardized rate | Europe | 12.4 | 13.6 | 17.1 | 17.6 | 12.5 | 15.5 | 14.2 | 12.1 | 14.3 (13.4‑15.3) |
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Standardized rate | World | 9.4 | 10.2 | 12.8 | 13.4 | 9.5 | 11.6 | 10.2 | 8.8 | 10.7 (9.9‑11.5) |
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Table 2: Mortality: frequencies, crude and standardized rates per year
Mortality | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 30 | 34 | 25 | 21 | 25 | 32 | 30 | 32 | 229 |
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Crude rate | 5.0 | 5.7 | 4.2 | 3.6 | 4.3 | 5.4 | 4.9 | 5.2 | 4.8 (4.2‑5.5) |
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Standardized rate | Italy 2001 | 5.0 | 5.9 | 4.5 | 3.2 | 4.3 | 5.2 | 4.8 | 5.3 | 4.8 (4.2‑5.5) |
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Standardized rate | Europe | 3.7 | 3.9 | 2.8 | 2.6 | 2.8 | 3.9 | 3.2 | 3.8 | 3.3 (2.9‑3.8) |
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Standardized rate | World | 2.6 | 2.5 | 1.9 | 2.0 | 1.9 | 2.7 | 2.2 | 2.7 | 2.3 (2.0‑2.7) |
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Table 3: Register quality indicators per year
Indicator | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Mortality/Incidence ratio (%) | 32.3 | 34.1 | 20.1 | 14.3 | 27.4 | 25.2 | 26.1 | 32.9 | 25.9 |
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Cito-histologically confirmed (%) | 100.0 | 98.1 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 99.8 |
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Death certificate only - DCO (%) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
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Table 4: Comparison of Italian Registries mean prevalence by macro-areas
_ | Milan | North West | North East | Centre | South | Italy |
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Incidence | 13.6 | 12.6 | 12.6 | 11.9 | 6.9 | 11.4 |
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Mortality | 3.4 | 2.8 | 3.0 | 2.5 | 2.1 | 2.7 |
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Table 5: Basis of diagnosis per period
_ | 1999‑2002 | % | 2003‑2006 | % | 1999‑2006 | % |
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Histological | 470 | 99.6 | 445 | 100.0 | 915 | 99.8 |
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Citological | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
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Clinical | 2 | 0.4 | 0 | 0.0 | 2 | 0.2 |
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DCO | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
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Table 6: More frequent morphologies
Morphology | N | % |
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Superficial spreading melanoma (C44._) | 178 | 40.0 |
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Epithelioid cell melanoma | 121 | 27.2 |
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Malignant melanoma, NOS (except juvenile melanoma M87700) | 61 | 13.7 |
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Nodular melanoma (C44._) | 31 | 7.0 |
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Mixed epithelioid and spindle cell melanoma | 23 | 5.2 |
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Lentigo maligna melanoma (C44._) | 18 | 4.0 |
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Table 7: Age distribution of rates
Age groups | Incidence | Mortality |
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0 | 0.0 | 0.0 |
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1-4 | 0.0 | 0.0 |
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5-9 | 0.0 | 0.0 |
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10-14 | 1.1 | 0.0 |
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15-19 | 3.4 | 0.0 |
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20-24 | 1.9 | 0.0 |
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25-29 | 3.1 | 0.6 |
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30-34 | 9.4 | 0.9 |
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35-39 | 8.2 | 2.2 |
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40-44 | 10.5 | 1.0 |
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45-49 | 12.2 | 1.2 |
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50-54 | 19.0 | 4.8 |
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55-59 | 30.8 | 7.5 |
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60-64 | 32.6 | 12.1 |
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65-69 | 46.3 | 9.9 |
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70-74 | 38.5 | 11.8 |
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75-79 | 63.1 | 17.1 |
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80-84 | 52.9 | 18.8 |
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85+ | 46.9 | 35.2 |
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Table 8: Temporal trends of rates
Year | Mortality | Incidence |
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1999 | 3.7 | 12.4 |
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2000 | 3.9 | 13.6 |
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2001 | 2.8 | 17.1 |
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2002 | 2.6 | 17.6 |
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2003 | 2.8 | 12.5 |
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2004 | 3.9 | 15.5 |
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2005 | 3.2 | 14.2 |
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2006 | 3.8 | 12.1 |
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Table 10: Comparison of Italian Registries mean prevalence by macro-areas
Years since diagnosis | Italy | South | Centre | North East | North West | Milan |
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0-2 | 28.8 | 12.5 | 28.5 | 31.7 | 35.7 | 41.4 |
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2-5 | 33.1 | 16.0 | 32.9 | 35.6 | 41.3 | 49.4 |
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5-10 | 35.4 | 14.7 | 38.5 | 36.3 | 45.4 | 49.0 |
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10-15 | 20.7 | 8.5 | 18.4 | 26.0 | 23.4 | 28.5 |
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15-20 | 10.1 | 5.0 | 8.8 | 11.2 | 12.7 | 14.9 |
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>20 | 8.3 | 3.5 | 8.9 | 9.1 | 10.1 | 12.3 |
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Table 11: 5 years relative survival by macro-areas
Area | Relative survival (95% CI) |
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Milan | 82.4 (78.6‑86.2) |
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North West | 83.6 (81.5‑85.5) |
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North Est | 82.1 (80.3‑83.8) |
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Centre | 81.7 (78.5‑84.5) |
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South | 72.5 (68.0‑76.6) |
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Italy | 81.6 (80.4‑82.8) |
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Table 12: Relative survival by age since diagnosis
Age class | 0 | 1 | 2 | 3 | 4 | 5 |
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15-44 | 100.00 | 98.30 | 96.60 | 93.60 | 91.20 | 90.70 |
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45-59 | 100.00 | 95.60 | 90.60 | 86.70 | 85.10 | 82.20 |
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60-74 | 100.00 | 90.60 | 84.10 | 81.30 | 79.40 | 75.60 |
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75+ | 100.00 | 97.10 | 88.70 | 82.50 | 79.20 | 77.90 |
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Table 13: 5 years relative survival by biennium of incidence
Years since diagnosis | 1999‑2000 | 2001‑2002 | 2003‑2004 | 2005‑2006 |
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1 | 94.8 | 96.1 | 94 | 93.3 |
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2 | 89.1 | 92.1 | 87.6 | 86 |
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3 | 83.6 | 89.7 | 83.7 | 82.5 |
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4 | 80.9 | 86.7 | 82.9 | 80.5 |
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5 | 76.8 | 83.1 | 81.7 | 79.3 |
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Table 14: Rates distribution by deprivation index
‑ | 1 | 2 | 3 | 4 | 5 |
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Incidence | 23 | 18.5 | 15.5 | 15.6 | 14.3 |
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Mortality | 6.6 | 2.5 | 5 | 3.3 | 5 |
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Table 15: Relative survival by deprivation index
Years since diagnosis | Most deprived | Most affluent |
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0 | 100.0 | 100.0 |
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1 | 92.0 | 92.8 |
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2 | 80.3 | 88.1 |
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3 | 78.3 | 80.5 |
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4 | 76.4 | 77.1 |
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5 | 76.2 | 76.0 |
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