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Multiple myeloma and immunoproliferative neoplasms - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		46	48	56	62	52	60	48	59	431
Crude rate		7.7	8.1	9.5	10.6	8.9	10.1	7.8	9.5	9.0 (8.2‑9.9)
Standardized rate	Italy 2001	8.0	8.3	9.2	10.5	8.6	9.7	7.9	9.4	9.0 (8.1‑9.9)
Standardized rate	Europe	5.3	5.4	6.6	7.1	5.9	6.5	5.3	6.4	6.1 (5.5‑6.7)
Standardized rate	World	3.5	3.6	4.7	4.7	4.2	4.4	3.5	4.4	4.1 (3.7‑4.6)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		24	29	39	34	35	41	31	24	257
Crude rate		4.0	4.9	6.6	5.8	6.0	6.9	5.1	3.9	5.4 (4.7‑6.1)
Standardized rate	Italy 2001	4.6	5.1	7.2	5.9	6.1	6.4	5.2	4.1	5.6 (4.9‑6.3)
Standardized rate	Europe	2.8	3.1	4.0	3.5	3.9	3.9	3.4	2.4	3.4 (3.0‑3.8)
Standardized rate	World	1.8	2.1	2.4	2.2	2.5	2.5	2.3	1.4	2.1 (1.9‑2.5)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	57.5	61.4	78.3	56.2	70.9	66.0	65.8	43.6	62.2
Cito-histologically confirmed (%)	100.0	91.7	100.0	98.4	80.8	76.7	66.7	74.6	86.1
Death certificate only - DCO (%)	0.0	4.2	0.0	0.0	0.0	3.3	2.1	1.7	1.4

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	6.0	6.8	6.2	6.2	5.5	6.2
Mortality	3.4	3.7	3.4	3.0	3.1	3.3

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	207	97.6	164	74.9	371	86.1
Citological	0	0.0	0	0.0	0	0.0
Clinical	3	1.4	50	22.8	53	12.3
DCO	2	0.9	4	1.8	6	1.4

Table 6: More frequent morphologies

Morphology	N	%
Multiple myeloma (C42.1)	155	94.5
Waldenstr÷m's macroglobulinaemia (C42.0) (see also M96713)	3	1.8
Plasmacytoma, extramedullary (not occurring in bone)	3	1.8
Plasma cell leukaemia (C42.1)	1	0.6
Plasmacytoma, NOS	1	0.6
Acinar cell carcinoma	1	0.6

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	0.0	0.0
25-29	0.0	0.0
30-34	0.4	0.0
35-39	0.9	0.0
40-44	1.0	0.0
45-49	6.7	1.2
50-54	6.1	0.7
55-59	7.5	4.4
60-64	21.1	10.9
65-69	21.8	17.2
70-74	33.0	14.1
75-79	35.3	15.0
80-84	42.7	47.8
85+	46.9	52.7

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	2.8	5.3
2000	3.1	5.4
2001	4.0	6.6
2002	3.5	7.1
2003	3.9	5.9
2004	3.9	6.5
2005	3.4	5.3
2006	2.4	6.4

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	13.3	10.5	12.8	13.1	16.0	10.2
2-5	12.2	7.6	13.2	13.8	12.3	11.7
5-10	9.2	7.7	8.9	9.5	9.3	9.9
10-15	4.5	2.9	4.0	6.5	3.1	3.9
15-20	1.3	1.1	0.9	1.5	1.2	1.3
>20	0.5	0.3	0.8	0.5	0.4	0.4

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	48.1 (41.6‑54.6)
North West	44.7 (41.4‑48.1)
North Est	47.8 (45.0‑50.5)
Centre	48.2 (43.4‑52.8)
South	42.5 (37.4‑47.6)
Italy	46.1 (44.3‑47.9)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	90.30	89.10	83.20	76.90	74.50
45-59	100.00	75.90	62.30	55.70	51.30	47.00
60-74	100.00	68.50	53.70	43.20	33.20	28.20

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	78.7	77.1	74.8	74.7
2	63	67.1	64.8	63.5
3	59	61.3	56.4	51.3
4	56.2	52.9	48.7	46.2
5	44.4	50.4	45.5	45.2

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	8.9	9	8.5	7.8	8.8
Mortality	5.5	4.4	6.1	4.5	5.2

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	71.4	65.3
2	64.8	52.1
3	48.4	50.8
4	39.9	49.9
5	35.4	48.9