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PdfMultiple myeloma and immunoproliferative neoplasms - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence199920002001200220032004200520061999‑2006
Count4648566252604859431
Crude rate7.78.19.510.68.910.17.89.59.0 (8.2‑9.9)
Standardized rateItaly 20018.08.39.210.58.69.77.99.49.0 (8.1‑9.9)
Standardized rateEurope5.35.46.67.15.96.55.36.46.1 (5.5‑6.7)
Standardized rateWorld3.53.64.74.74.24.43.54.44.1 (3.7‑4.6)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality199920002001200220032004200520061999‑2006
Count2429393435413124257
Crude rate4.04.96.65.86.06.95.13.95.4 (4.7‑6.1)
Standardized rateItaly 20014.65.17.25.96.16.45.24.15.6 (4.9‑6.3)
Standardized rateEurope2.83.14.03.53.93.93.42.43.4 (3.0‑3.8)
Standardized rateWorld1.82.12.42.22.52.52.31.42.1 (1.9‑2.5)

Table 3: Register quality indicators per year

Indicator199920002001200220032004200520061999‑2006
Mortality/Incidence ratio (%)57.561.478.356.270.966.065.843.662.2
Cito-histologically confirmed (%)100.091.7100.098.480.876.766.774.686.1
Death certificate only - DCO (%)0.04.20.00.00.03.32.11.71.4

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04
_MilanNorth WestNorth EastCentreSouthItaly
Incidence6.06.86.26.25.56.2
Mortality3.43.73.43.03.13.3

Table 5: Basis of diagnosis per period

_1999‑2002%2003‑2006%1999‑2006%
Histological20797.616474.937186.1
Citological00.000.000.0
Clinical31.45022.85312.3
DCO20.941.861.4

Table 6: More frequent morphologies

MorphologyN%
Multiple myeloma (C42.1)15594.5
Waldenstr÷m's macroglobulinaemia (C42.0) (see also M96713)31.8
Plasmacytoma, extramedullary (not occurring in bone)31.8
Plasma cell leukaemia (C42.1)10.6
Plasmacytoma, NOS10.6
Acinar cell carcinoma10.6

Table 7: Age distribution of rates

Graf 07
Age groupsIncidenceMortality
00.00.0
1-40.00.0
5-90.00.0
10-140.00.0
15-190.00.0
20-240.00.0
25-290.00.0
30-340.40.0
35-390.90.0
40-441.00.0
45-496.71.2
50-546.10.7
55-597.54.4
60-6421.110.9
65-6921.817.2
70-7433.014.1
75-7935.315.0
80-8442.747.8
85+46.952.7

Table 8: Temporal trends of rates

Graf 08
YearMortalityIncidence
19992.85.3
20003.15.4
20014.06.6
20023.57.1
20033.95.9
20043.96.5
20053.45.3
20062.46.4

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10
Years since diagnosisItalySouthCentreNorth EastNorth WestMilan
0-213.310.512.813.116.010.2
2-512.27.613.213.812.311.7
5-109.27.78.99.59.39.9
10-154.52.94.06.53.13.9
15-201.31.10.91.51.21.3
>200.50.30.80.50.40.4

Table 11: 5 years relative survival by macro-areas

Graf 11
AreaRelative survival (95% CI)
Milan48.1 (41.6‑54.6)
North West44.7 (41.4‑48.1)
North Est47.8 (45.0‑50.5)
Centre48.2 (43.4‑52.8)
South42.5 (37.4‑47.6)
Italy46.1 (44.3‑47.9)

Table 12: Relative survival by age since diagnosis

Age class012345
15-44100.0090.3089.1083.2076.9074.50
45-59100.0075.9062.3055.7051.3047.00
60-74100.0068.5053.7043.2033.2028.20

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis1999‑20002001‑20022003‑20042005‑2006
178.777.174.874.7
26367.164.863.5
35961.356.451.3
456.252.948.746.2
544.450.445.545.2

Table 14: Rates distribution by deprivation index

12345
Incidence8.998.57.88.8
Mortality5.54.46.14.55.2

Table 15: Relative survival by deprivation index

Years since diagnosisMost deprivedMost affluent
0100.0100.0
171.465.3
264.852.1
348.450.8
439.949.9
535.448.9