Multiple myeloma and immunoproliferative neoplasms - LadiesRates per 100,000 inhabitants
Table 1: Incidence: frequencies, crude and standardized rates per year
Incidence | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 65 | 59 | 65 | 46 | 58 | 63 | 57 | 51 | 464 |
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Crude rate | 9.6 | 8.7 | 9.7 | 6.9 | 8.7 | 9.3 | 8.3 | 7.4 | 8.6 (7.8‑9.4) |
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Standardized rate | Italy 2001 | 7.1 | 6.5 | 7.5 | 4.9 | 6.4 | 6.5 | 6.2 | 5.6 | 6.3 (5.8‑6.9) |
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Standardized rate | Europe | 4.5 | 4.3 | 5.5 | 3.2 | 4.4 | 3.9 | 4.4 | 4.0 | 4.3 (3.9‑4.7) |
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Standardized rate | World | 2.9 | 2.9 | 3.8 | 2.1 | 3.0 | 2.5 | 3.0 | 2.7 | 2.9 (2.6‑3.2) |
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Table 2: Mortality: frequencies, crude and standardized rates per year
Mortality | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Count | 43 | 44 | 38 | 39 | 42 | 40 | 44 | 36 | 326 |
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Crude rate | 6.3 | 6.5 | 5.6 | 5.8 | 6.3 | 5.9 | 6.4 | 5.2 | 6.0 (5.4‑6.7) |
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Standardized rate | Italy 2001 | 4.4 | 4.7 | 4.0 | 4.1 | 4.4 | 3.9 | 4.2 | 3.9 | 4.2 (3.8‑4.7) |
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Standardized rate | Europe | 2.6 | 3.0 | 2.4 | 2.7 | 2.7 | 2.1 | 2.4 | 2.6 | 2.5 (2.2‑2.9) |
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Standardized rate | World | 1.6 | 2.0 | 1.5 | 1.7 | 1.7 | 1.2 | 1.4 | 1.7 | 1.6 (1.4‑1.8) |
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Table 3: Register quality indicators per year
Indicator | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 1999‑2006 |
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Mortality/Incidence ratio (%) | 62.0 | 72.3 | 53.3 | 83.7 | 68.8 | 60.0 | 67.7 | 69.6 | 66.7 |
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Cito-histologically confirmed (%) | 87.7 | 91.5 | 98.5 | 95.7 | 84.5 | 73.0 | 68.4 | 72.6 | 84.1 |
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Death certificate only - DCO (%) | 4.6 | 1.7 | 0.0 | 2.2 | 1.7 | 1.6 | 1.8 | 3.9 | 2.2 |
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Table 4: Comparison of Italian Registries mean prevalence by macro-areas
_ | Milan | North West | North East | Centre | South | Italy |
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Incidence | 4.2 | 4.2 | 5.0 | 4.4 | 4.1 | 4.6 |
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Mortality | 2.4 | 2.6 | 2.5 | 2.4 | 2.3 | 2.4 |
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Table 5: Basis of diagnosis per period
_ | 1999‑2002 | % | 2003‑2006 | % | 1999‑2006 | % |
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Histological | 219 | 93.2 | 171 | 74.7 | 390 | 84.1 |
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Citological | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
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Clinical | 11 | 4.7 | 53 | 23.1 | 64 | 13.8 |
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DCO | 5 | 2.1 | 5 | 2.2 | 10 | 2.2 |
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Table 6: More frequent morphologies
Morphology | N | % |
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Multiple myeloma (C42.1) | 162 | 94.7 |
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Waldenstr÷m's macroglobulinaemia (C42.0) (see also M96713) | 7 | 4.1 |
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Plasmacytoma, NOS | 1 | 0.6 |
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Plasmacytoma, extramedullary (not occurring in bone) | 1 | 0.6 |
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Table 7: Age distribution of rates
Age groups | Incidence | Mortality |
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0 | 0.0 | 0.0 |
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1-4 | 0.0 | 0.0 |
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5-9 | 0.0 | 0.0 |
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10-14 | 0.0 | 0.0 |
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15-19 | 0.0 | 0.0 |
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20-24 | 0.0 | 0.0 |
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25-29 | 0.0 | 0.0 |
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30-34 | 0.0 | 0.0 |
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35-39 | 0.5 | 0.0 |
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40-44 | 0.5 | 0.0 |
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45-49 | 1.8 | 0.0 |
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50-54 | 3.6 | 1.8 |
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55-59 | 10.1 | 2.7 |
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60-64 | 14.1 | 4.2 |
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65-69 | 15.6 | 7.3 |
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70-74 | 22.8 | 19.9 |
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75-79 | 27.2 | 23.9 |
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80-84 | 25.1 | 28.6 |
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85+ | 31.8 | 27.8 |
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Table 8: Temporal trends of rates
Year | Mortality | Incidence |
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1999 | 2.6 | 4.5 |
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2000 | 3.0 | 4.3 |
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2001 | 2.4 | 5.5 |
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2002 | 2.7 | 3.2 |
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2003 | 2.7 | 4.4 |
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2004 | 2.1 | 3.9 |
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2005 | 2.4 | 4.4 |
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2006 | 2.6 | 4.0 |
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Table 10: Comparison of Italian Registries mean prevalence by macro-areas
Years since diagnosis | Italy | South | Centre | North East | North West | Milan |
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0-2 | 12.0 | 9.4 | 11.9 | 14.1 | 10.6 | 7.8 |
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2-5 | 10.0 | 7.6 | 10.2 | 11.5 | 8.9 | 10.8 |
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5-10 | 9.0 | 5.9 | 10.0 | 9.4 | 8.9 | 8.7 |
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10-15 | 4.7 | 2.6 | 4.9 | 7.1 | 3.1 | 4.1 |
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15-20 | 1.7 | 1.2 | 1.8 | 2.2 | 1.2 | 1.6 |
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>20 | 0.7 | 0.4 | 0.7 | 0.8 | 0.8 | 0.6 |
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Table 11: 5 years relative survival by macro-areas
Area | Relative survival (95% CI) |
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Milan | 44.2 (36.6‑51.8) |
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North West | 42.2 (38.6‑45.6) |
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North Est | 47.7 (45.1‑50.3) |
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Centre | 48.7 (44.0‑53.3) |
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South | 49.1 (44.5‑53.6) |
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Italy | 46.6 (44.9‑48.4) |
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Table 12: Relative survival by age since diagnosis
Age class | 0 | 1 | 2 | 3 | 4 | 5 |
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15-44 | 100.00 | 90.00 | 83.10 | 76.00 | 72.50 | 69.10 |
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45-59 | 100.00 | 86.70 | 76.70 | 65.50 | 57.70 | 52.30 |
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60-74 | 100.00 | 62.10 | 44.40 | 38.10 | 26.20 | 24.50 |
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Table 13: 5 years relative survival by biennium of incidence
Years since diagnosis | 1999‑2000 | 2001‑2002 | 2003‑2004 | 2005‑2006 |
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1 | 81 | 78.2 | 69.7 | 77.1 |
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2 | 64.8 | 65.4 | 56.5 | 68.4 |
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3 | 51.6 | 55.2 | 50.4 | 63.3 |
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4 | 38.8 | 43.5 | 45 | 59.1 |
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5 | 34.6 | 38.2 | 42.5 | 55.1 |
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Table 14: Rates distribution by deprivation index
‑ | 1 | 2 | 3 | 4 | 5 |
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Incidence | 7 | 8.3 | 9.6 | 7.4 | 8.6 |
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Mortality | 5.3 | 5.6 | 8.1 | 4.9 | 5 |
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Table 15: Relative survival by deprivation index
Years since diagnosis | Most deprived | Most affluent |
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0 | 100.0 | 100.0 |
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1 | 69.7 | 70.4 |
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2 | 61.5 | 59.8 |
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3 | 58.7 | 54.9 |
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4 | 50.9 | 46.9 |
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5 | 45.6 | 46.9 |
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