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Bladder - Gents

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		365	340	389	379	272	283	273	290	2591
Crude rate		61.2	57.4	65.9	64.8	46.8	47.4	44.5	46.9	54.3 (52.2‑56.4)
Standardized rate	Italy 2001	64.5	60.3	67.6	65.8	45.7	46.8	44.2	47.4	54.9 (52.8‑57.1)
Standardized rate	Europe	40.5	38.6	42.9	40.7	29.5	29.3	27.6	30.1	34.7 (33.4‑36.1)
Standardized rate	World	26.5	25.2	27.7	26.2	19.2	19.1	17.8	19.4	22.5 (21.6‑23.5)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		112	112	127	123	104	103	103	87	871
Crude rate		18.8	18.9	21.5	21.0	17.9	17.3	16.8	14.1	18.2 (17.1‑19.5)
Standardized rate	Italy 2001	21.3	21.9	23.8	22.7	18.7	18.2	18.1	15.1	19.9 (18.6‑21.3)
Standardized rate	Europe	12.4	12.0	13.3	12.6	10.4	10.2	10.0	8.5	11.1 (10.4‑11.9)
Standardized rate	World	7.7	7.1	7.9	7.4	6.1	6.1	5.9	5.0	6.6 (6.2‑7.1)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	33.0	36.3	35.2	34.5	40.9	38.9	41.0	31.9	36.2
Cito-histologically confirmed (%)	90.7	90.6	92.0	95.3	95.2	92.2	93.0	93.8	92.8
Death certificate only - DCO (%)	0.8	0.6	1.3	0.0	0.0	1.1	0.7	0.3	0.6

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	29.1	58.4	46.4	48.6	55.3	49.7
Mortality	9.7	12.1	9.7	11.1	12.5	10.8

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	1807	91.5	1827	93.8	3634	92.7
Citological	53	2.7	48	2.5	101	2.6
Clinical	105	5.3	63	3.2	168	4.3
DCO	10	0.5	6	0.3	16	0.4

Table 6: More frequent morphologies

Morphology	N	%
Transitional cell carcinoma, NOS	523	50.0
Papillary transitional cell carcinoma (C67._)	454	43.4
Tumour cells, malignant	23	2.2
Transitional cell carcinoma, micropapillary (C67._)	8	0.8
Solid carcinoma, NOS	6	0.6
Carcinoma, NOS	4	0.4

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	0.0	0.0
25-29	0.0	0.0
30-34	0.0	0.4
35-39	1.3	0.0
40-44	4.5	0.5
45-49	5.5	0.0
50-54	22.4	6.1
55-59	45.8	5.0
60-64	83.6	16.6
65-69	120.4	27.1
70-74	151.6	43.2
75-79	212.8	104.8
80-84	305.7	138.3
85+	313.6	225.6

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	12.4	40.5
2000	12.0	38.6
2001	13.3	42.9
2002	12.6	40.7
2003	10.4	29.5
2004	10.2	29.3
2005	10.0	27.6
2006	8.5	30.1

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	117.8	115.8	121.8	117.0	117.8	73.4
2-5	141.5	122.8	153.6	134.8	158.4	120.6
5-10	156.7	149.7	189.2	138.8	177.2	144.8
10-15	105.8	89.2	111.4	107.9	104.4	82.3
15-20	56.9	49.8	66.0	55.8	57.8	48.4
>20	64.9	54.6	74.7	63.1	69.1	55.0

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	71.9 (69.1‑74.8)
North West	78.9 (77.8‑80.0)
North Est	78.9 (77.9‑79.9)
Centre	77.9 (76.4‑79.4)
South	77.0 (75.3‑78.5)
Italy	78.5 (77.9‑79.1)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	100.00	96.90	96.90	96.90	96.90
45-59	100.00	93.20	87.30	84.60	83.30	82.50
60-74	100.00	90.50	83.60	79.00	74.30	71.10
75+	100.00	77.00	68.10	63.10	60.50	59.30

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	86.5	85.5	86.1	83.2
2	80.3	80.4	76.4	72.6
3	75.5	75.2	72.6	68.2
4	71.4	72.3	68.5	64.8
5	68.8	69.2	66	63.8

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	38.7	33.5	45.8	47.8	55.1
Mortality	12.2	14.1	14.2	16.3	21.5

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	83.0	86.9
2	72.2	74.9
3	68.3	69.7
4	63.1	67.4
5	60.6	65.1