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Rectum, anus and anal canal - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		149	160	166	201	154	162	139	159	1290
Crude rate		21.9	23.7	24.7	30.1	23.1	24.0	20.3	23.0	23.8 (22.5‑25.2)
Standardized rate	Italy 2001	16.8	17.9	18.4	22.5	17.1	17.5	15.2	17.6	17.8 (16.8‑18.8)
Standardized rate	Europe	11.3	12.5	12.6	15.9	12.2	11.8	10.5	12.8	12.4 (11.7‑13.2)
Standardized rate	World	7.8	8.6	8.5	10.8	8.4	7.9	7.1	8.8	8.5 (7.9‑9.0)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		73	67	66	79	55	84	59	65	548
Crude rate		10.7	9.9	9.8	11.8	8.3	12.4	8.6	9.4	10.1 (9.3‑11.0)
Standardized rate	Italy 2001	7.6	7.0	6.9	8.2	5.7	8.2	5.9	6.6	7.0 (6.4‑7.6)
Standardized rate	Europe	4.3	4.0	4.3	5.1	3.7	5.0	3.6	4.2	4.2 (3.8‑4.7)
Standardized rate	World	2.6	2.4	2.8	3.3	2.5	3.1	2.2	2.8	2.7 (2.4‑3.0)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	45.2	39.1	37.5	36.4	33.3	46.9	38.8	37.5	39.3
Cito-histologically confirmed (%)	85.9	88.8	89.2	91.6	90.9	92.0	89.2	92.5	90.1
Death certificate only - DCO (%)	2.7	1.9	1.8	2.0	2.6	3.1	2.9	1.3	2.3

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	11.8	14.5	12.5	14.8	10.9	13.0
Mortality	4.1	4.1	3.9	3.2	2.6	3.6

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	601	88.9	560	91.2	1161	90.0
Citological	1	0.2	0	0.0	1	0.1
Clinical	60	8.9	38	6.2	98	7.6
DCO	14	2.1	15	2.4	29	2.3

Table 6: More frequent morphologies

Morphology	N	%
Adenocarcinoma, NOS	383	68.4
Squamous cell carcinoma, NOS	57	10.2
Mucinous adenocarcinoma	31	5.5
Adenocarcinoma in tubulovillous adenoma	26	4.6
Adenocarcinoma in villous adenoma	12	2.1
Adenocarcinoma in adenomatous polyp	9	1.6

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	0.0	1.0
25-29	0.6	0.0
30-34	0.5	0.9
35-39	0.5	0.9
40-44	4.0	0.5
45-49	7.6	1.8
50-54	21.0	3.6
55-59	24.9	5.8
60-64	38.2	9.9
65-69	41.2	11.5
70-74	50.7	13.7
75-79	63.1	25.2
80-84	74.5	56.3
85+	85.4	68.5

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	4.3	11.3
2000	4.0	12.5
2001	4.3	12.6
2002	5.1	15.9
2003	3.7	12.2
2004	5.0	11.8
2005	3.6	10.5
2006	4.2	12.8

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	33.9	22.4	40.1	33.6	38.2	34.0
2-5	34.0	23.2	40.1	33.2	39.0	42.0
5-10	36.8	20.5	50.1	35.5	42.3	42.6
10-15	24.1	13.7	29.5	23.2	28.5	26.0
15-20	14.1	7.9	18.3	13.8	16.0	15.7
>20	16.4	9.2	21.2	16.0	19.3	18.6

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	58.5 (54.5‑62.6)
North West	58.9 (56.9‑60.8)
North Est	58.0 (56.2‑59.8)
Centre	60.1 (57.4‑62.8)
South	55.7 (52.5‑58.8)
Italy	58.4 (57.2‑59.5)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	75.40	68.20	68.20	64.50	57.00
45-59	100.00	93.20	85.80	76.80	70.70	64.50
60-74	100.00	88.30	82.70	76.70	71.70	68.20
75+	100.00	71.10	59.90	55.10	50.20	46.60

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	80.8	80.6	82.8	81.9
2	73.2	71.6	73	75.1
3	67.2	67.2	67.5	66.7
4	62	59.9	63.3	62.9
5	55.9	55.2	59.7	59.5

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	21.4	21.3	21.1	23	22
Mortality	9.5	8.5	8.2	7.4	12.1

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	74.3	82.5
2	69.6	75.2
3	61.6	70.7
4	55.3	66.9
5	52.9	60.6